RESUMO
OBJECTIVES: This study aims to analyze data on the epidemiology, treatment and course of bullous pemphigoid in 50 patients and compare findings to the data already available in the literature. METHODS: Data were collected retrospectively through medical records and analyzed statistically. A review of the literature was conducted using articles indexed in the MEDLINE (via PubMed) database. RESULTS: The mean age at diagnosis was 71.1 years. Comorbidities were observed in almost all cases, and the association between bullous pemphigoid and neurological diseases was present in 18% of patients, in agreement with recent data in the literature. CONCLUSION: Care of comorbidities, especially neurological diseases, which increase the mortality of patients with bullous pemphigoid, is thus essential
OBJETIVOS: Este estudo tem por objetivo analisar dados epidemiológicos, de tratamento e evolução de 50 pacientes com diagnóstico de penfigoide bolhoso e comparar aos dados já existentes na literatura. MÉTODOS: Os dados foram coletados retrospectivamente por meio de prontuários médicos e analisados estatisticamente. Foi realizada revisão da literatura mediante artigos indexados na base de dados MEDLINE (via PubMed). RESULTADOS: A média de idade ao diagnóstico foi de 71,1 anos. Comorbidades foram observadas em quase a totalidade dos casos, e a associação entre penfigoide bolhoso e doenças neurológicas esteve presente em 18% dos pacientes, em concordância com dados recentes da literatura. CONCLUSÃO: Ressaltamos a atenção às comorbidades, sobretudo doenças neurológicas, que aumentam a mortalidade dos pacientes com penfigóide bolhoso
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Penfigoide Bolhoso/epidemiologia , Comorbidade , Estudos Retrospectivos , Penfigoide Bolhoso/tratamento farmacológicoRESUMO
Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults.
Assuntos
Dermatose Linear Bolhosa por IgA/diagnóstico , Dermatopatias Vesiculobolhosas/diagnóstico , Adulto , Diagnóstico Precoce , Feminino , Técnica Direta de Fluorescência para Anticorpo , Humanos , Dermatose Linear Bolhosa por IgA/patologia , Masculino , Pessoa de Meia-Idade , Doenças Raras , Dermatopatias Vesiculobolhosas/patologiaRESUMO
Abstract: Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Dermatopatias Vesiculobolhosas/diagnóstico , Dermatose Linear Bolhosa por IgA/diagnóstico , Dermatopatias Vesiculobolhosas/patologia , Técnica Direta de Fluorescência para Anticorpo , Doenças Raras , Diagnóstico Precoce , Dermatose Linear Bolhosa por IgA/patologiaRESUMO
Abstract Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. We report a case of well-differentiated invasive squamous cell carcinoma arising from a multiple verrucous epidermal nevus. Although there is no consensus on prophylactic removal of epidermal nevus, its removal and biopsy should be considered if changes occur.
Assuntos
Humanos , Masculino , Adulto , Neoplasias Cutâneas/etiologia , Carcinoma de Células Escamosas/etiologia , Nevo Sebáceo de Jadassohn/complicações , Neoplasias Cutâneas/patologia , Úlcera Cutânea/patologia , Biópsia , Carcinoma de Células Escamosas/patologia , Epiderme/patologia , Nevo Sebáceo de Jadassohn/patologia , Neoplasias Primárias Múltiplas/complicações , Neoplasias Primárias Múltiplas/patologiaRESUMO
Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. We report a case of well-differentiated invasive squamous cell carcinoma arising from a multiple verrucous epidermal nevus. Although there is no consensus on prophylactic removal of epidermal nevus, its removal and biopsy should be considered if changes occur.
